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3,4-Dihydroxystyrene

3,4-Dihydroxystyrene
Clinical data
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • 4-Ethenylbenzene-1,2-diol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC8H8O2
Molar mass136.150 g·mol−1
3D model (JSmol)
  • Oc1ccc(\C=C)cc1O
  • InChI=1S/C8H8O2/c1-2-6-3-4-7(9)8(10)5-6/h2-5,9-10H,1H2 checkY
  • Key:FBTSUTGMWBDAAC-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

3,4-Dihydroxystyrene (DHS) is a centrally-acting inhibitor of the enzyme phenylalanine hydroxylase (PH).[1] It is likely that DHS and other PH inhibitors will never have clinical applications on account of their capacity for inducing hyperphenylalaninemia and phenylketonuria.[citation needed]

See also

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References

[edit]
  1. ^ Koizumi S, Matsushima Y, Nagatsu T, Iinuma H, Takeuchi T, Umezawa H (September 1984). "3,4-dihydroxystyrene, a novel microbial inhibitor for phenylalanine hydroxylase and other pteridine-dependent monooxygenases". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 789 (2): 111–8. doi:10.1016/0167-4838(84)90194-8. PMID 6148105.
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