He studied medicine, zoology and botany at Erlangen, and following graduation spent time in Berlin (from 1804) and Paris (from 1806). In 1809 he was appointed professor of botany and medicine at the University of Königsberg. In 1815, he was elected a corresponding member of the Royal Swedish Academy of Sciences. On a research trip to Sicily, he was murdered near Agrigento on 28 June 1821.
In the scientific field of herpetology, he is best known for his 1812 monograph of turtles, in which he described several new species which are still valid.
Einige Worte über Classification der Thiere, (Treatise on the classification of animals), 1812.
Prodromi monographiae cheloniorum, 1814.
Beobachtungen auf naturhistorischen Reisen (Observations on natural history trips). Berlin, 1819.
Handbuch der Naturgeschichte der skelettlosen ungegliederten Tiere (Textbook of natural history on unsegmented invertebrates). Leipzig, 1820.
De plantarum classificatione naturalis, 1821.
"The Life and Herpetological Contributions of August Friedrich Schweigger" (Published in English); Society for the Study of Amphibians and Reptiles, 2008.[3]