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Chlorisondamine

Chlorisondamine
Clinical data
ATC code
  • None
Identifiers
  • Trimethyl-[2-(4,5,6,7-tetrachloro-2-methyl-isoindolin-2-ium-2-yl)ethyl]ammonium dichloride
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H20Cl6N2
Molar mass429.03 g·mol−1
3D model (JSmol)
  • [Cl-].[Cl-].Clc1c2c(c(Cl)c(Cl)c1Cl)C[N+](C2)(C)CC[N+](C)(C)C
  • InChI=1S/C14H20Cl4N2/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15/h5-8H2,1-4H3/q+2 checkY
  • Key:IXWDUZLHWJKVPX-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Chlorisondamine is a nicotinic acetylcholine receptor antagonist that produces both neuronal and ganglionic blockade.

Chlorisondamine has been shown to form noncovalent complexes with various biomolecules including sphingomyelin and other associated glycolipids.[1][2][3]

References

[edit]
  1. ^ Woods AS, Moyer SC, Wang HY, Wise RA (2003). "Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor". Journal of Proteome Research. 2 (2): 207–12. doi:10.1021/pr025578h. PMID 12716135.
  2. ^ Jackson SN, Wang HY, Woods AS, Ugarov M, Egan T, Schultz JA (February 2005). "Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS". Journal of the American Society for Mass Spectrometry. 16 (2): 133–8. Bibcode:2005JASMS..16..133J. doi:10.1016/j.jasms.2004.10.002. PMID 15694763. S2CID 5894935.
  3. ^ Woods AS, Ugarov M, Egan T, Koomen J, Gillig KJ, Fuhrer K, Gonin M, Schultz JA (April 2004). "Lipid/peptide/nucleotide separation with MALDI-ion mobility-TOF MS". Analytical Chemistry. 76 (8): 2187–95. doi:10.1021/ac035376k. PMID 15080727.
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