The Colbert family is of 15/16ths Irish ancestry; one of her paternal great-great-grandmothers was of German and English descent.[9][10] Many of her ancestors emigrated from Ireland to North America in the 19th century before and during the Great Famine.[11][12][13][10]
After graduating, she completed a South Carolina State Ports Authority business development internship, and worked for Associated Maritime Industries Inc, as a liaison between the AMI and the U.S. Federal and State Governments.[16] She then worked as the Regional Director for Sales and Marketing and the Director of Business Development at Orient Overseas Container Line (OOCL), where she was responsible for international maritime relations and South Atlantic and North American sales.[17][18] She left OOCL in 2008, when she was hired as Director of Business Development at Clemson University's Restoration Institute, described by the Charleston Post and Courier as "the school's corporate matchmaker" for the university's development projects for wind turbine testing, water studies, and renewable energy.[16][19] Colbert Busch also works as the Director of Sales and Marketing for Clemson's Wind Turbine Drivetrain Testing Facility.[20]
Colbert Busch is a founder and former member of the Executive Board of Directors of Charleston Women in International Trade, and former member of the College of Charleston's Business College Alumni Advisory Board.[21] She has served as chairwoman of the 2006 S.C. International Trade Conference, the chairwoman of the Maritime Association Port of Charleston and is board member of the Charleston Metro Chamber of Commerce.[22][23]
On February 11, 2013, Martin Skelly dropped out of the race, endorsing Colbert Busch.[26]
On March 19, 2013, Colbert Busch handily won the Democratic primary with over 95% of the vote compared to perennial candidate Ben Frasier's 4%. In the special election she was defeated by former South Carolina GovernorMark Sanford.[27][28] Colbert Busch garnered 45.3% of the vote compared to Sanford's 54.2%.[29]
Elizabeth Colbert Busch is married to Claus Wyman Busch III. She has three children with her ex-husband Robert Legare: Mary Legare Middleton (grandchildren Elizabeth Ann and Thomas Bradley Middleton Jr.); Robert Walker Legare Jr; and Catherine Ann Legare.[15]
She was arrested in 1988 for contempt of court during her divorce from her previous husband.[31]