From a wealthy family, he entered the Dominican Order in 1743 at Málaga, Spain, teaching philosophy during 1751–1756, theology, 1756–1758, and Holy Scriptures, 1758–1761. He moved to Cádiz, the seafaring gate of trade to the American Spanish Empire and earned a doctorate of divinity in nearby Jerez de la Frontera in 1767 He became a prior to sieges of the Dominican Order in Málaga, Almería, Cabra, Ciudad Real and Doña Mencía, training teachers of Christianity, dictionary editors and administrative tutors in aboriginal American Indian languages, North and South America, after the middle of the 16th Century.
Difficulties on the Island of Hispaniola around 1798 led him to move the supposed remains of seafarer and discoverer Christopher Columbus to La Habana, Cuba, being kept at the Convent of San Juan de Letrán. Portillo was proposed by the Spanish Crown to the Roman Pope in 1798 as a Bishop of Trujillo, Peru, but instead Portillo became Archbishop of Bogotá, a much higher position. Del Portillo y Torres died in 1804, aged around 75.
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Cuban convents in the age of Enlightened Reform, 1761-1807 By John James Clune; University Press of Florida, 2008; ISBN0-8130-3217-2.
Historia ecclesiastica, Part 4 By Juan Manuel Pacheco;Ediciones Lerner, 1971.
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Haïti 1804—lumières et ténébres: impact et résonances d'une révolution By Léon-François Hoffmann, Frauke Gewecke, Ulrich Fleischmann; Iberoamericana Editorial, 2008; ISBN84-8489-371-5.