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Melzo is an unincorporated community in southern Jefferson County, in the U.S. state of Missouri.[1] The community is located on Missouri Route E just north of the Jefferson-St. Francois county line. DeSoto is eight miles to the north and Bone Terre is approximately six miles to the south.[2]
A post office called Melzo was established in 1906, and remained in operation until 1938.[3] An early postmaster gave the community the first name of his son, Melzo Higginbotham.[4]
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38°00′36″N 90°34′10″W / 38.01000°N 90.56944°W