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Names | |
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IUPAC name
Sodium vanadate(V)
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Other names
Sodium vanadium oxide
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Identifiers | |
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3D model (JSmol)
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ChEBI | |
ChEMBL | |
ECHA InfoCard | 100.033.883 |
PubChem CID
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RTECS number |
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
Na3VO4 | |
Molar mass | 183.908 g/mol |
Appearance | white powder |
Density | 2.16 g/cm3, solid |
Melting point | 858 °C (1,576 °F; 1,131 K) |
22.17 g/100 mL | |
Solubility | insoluble in ethanol |
Structure | |
cubic | |
Thermochemistry | |
Heat capacity (C)
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164.8 J/mol K |
Std molar
entropy (S⦵298) |
190 J/mol K |
Std enthalpy of
formation (ΔfH⦵298) |
−1757 kJ/mol |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Harmful. |
NFPA 704 (fire diamond) | |
Flash point | Non-flammable |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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330 mg/kg (oral, rat) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Sodium orthovanadate is the inorganic compound with the chemical formula Na3V O4. It forms a dihydrate Na3VO4·2H2O. Sodium orthovanadate is a salt of the VO3−4 oxyanion. It is a colorless, water-soluble solid.[2]
Sodium orthovanadate is produced by dissolving vanadium(V) oxide in a solution of sodium hydroxide:
The salt features tetrahedral VO3−4 anion centers linked to octahedral Na+ cation sites.[3]
Like many oxometalates, orthovanadate is subject to a number of reactions, which have been analyzed by 51V NMR studies. At high pH, VO3−4 ions exist in equilibrium with HVO2−4.[4] At lower pH's, condensation ensues to give various polyoxovanadates. Ultimately, decavanadate is formed.[5]
Vanadates exhibit a variety of biological activities, in part because they serve as structural mimics of phosphates.[6][7] It acts as a competitive inhibitor of ATPases, alkaline and acid phosphatases, and protein-phosphotyrosine phosphatases,[8] and its inhibitory effects can be reversed by dilution or the addition of ethylenediaminetetraacetic acid (EDTA).[9]
Orthovanadate is activated by boiling and adjusting pH to ~10; this depolymerizes decavanadate into the active inhibitor, monovanadate.[8]
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