Spoo may refer to:
- Bob Spoo (1937–2018), American college football coach
- Caspar Mathias Spoo (1837–1914), Luxembourgish industrialist and politician
- Robert Spoo (born 1957), American legal scholar and educator
- Spoo (food), a fictional food in the Babylon 5 science fiction television series
This disambiguation page lists articles associated with the title Spoo.
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