TRIP12

TRIP12
Identifiers
Aliases	TRIP12, TRIP-12, ULF, thyroid hormone receptor interactor 12
External IDs	OMIM: 604506; MGI: 1309481; HomoloGene: 44226; GeneCards: TRIP12; OMA:TRIP12 - orthologs
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	84,840,516 bp
RNA expression pattern
	n/a
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; Gonadal ridge; ; primitive streak; ; medullary collecting duct; ; hair follicle; ; conjunctival fornix; ; primary oocyte; ; urothelium;
	More reference expression data
Gene ontology
Molecular function	thyroid hormone receptor binding; protein binding; ubiquitin-protein transferase activity; transferase activity; ubiquitin protein ligase activity;
Cellular component	nucleus; nucleoplasm; cytosol; nuclear speck; cytoplasm;
Biological process	negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; DNA repair; protein ubiquitination; embryo development; cellular response to DNA damage stimulus; protein polyubiquitination; ubiquitin-dependent protein catabolic process; regulation of embryonic development;
	Sources:Amigo / QuickGO
Orthologs
	9320
	14897
	ENSG00000153827
	ENSMUSG00000026219
	Q14669
	G5E870
	NM_001284214; NM_001284215; NM_001284216; NM_004238
	NM_133975
NP_001271143; NP_001271144; NP_001271145; NP_004229; NP_001335244;
	NP_001335245; NP_001335246; NP_001335247; NP_001335248; NP_001335249; NP_001335250; NP_001335251; NP_001335252; NP_001335253; NP_001335254; NP_001335255; NP_001335256; NP_001335257; NP_001335258; NP_001335259; NP_001335260; NP_001335261; NP_001335262; NP_001335263; NP_001335264; NP_001335265
	NP_598736
	Wikidata
View/Edit Human	View/Edit Mouse

Probable E3 ubiquitin-protein ligase TRIP12 is an enzyme that in humans is encoded by the TRIP12 gene.^[4]^[5]

Interactions

TRIP12 has been shown to interact with APPBP1.^[6]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026219 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Jul 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/mend.9.2.7776974. PMID 7776974.
^ "Entrez Gene: TRIP12 thyroid hormone receptor interactor 12".
^ Park, Yoon; Yoon Sungjoo Kim; Yoon Jong-Bok (Sep 2008). "TRIP12 functions as an E3 ubiquitin ligase of APP-BP1". Biochem. Biophys. Res. Commun. 374 (2). United States: 294–8. doi:10.1016/j.bbrc.2008.07.019. PMID 18627766.

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000026219 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7776974-4] Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Jul 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/mend.9.2.7776974. PMID 7776974.

[entrez-5] "Entrez Gene: TRIP12 thyroid hormone receptor interactor 12".

[pmid18627766-6] Park, Yoon; Yoon Sungjoo Kim; Yoon Jong-Bok (Sep 2008). "TRIP12 functions as an E3 ubiquitin ligase of APP-BP1". Biochem. Biophys. Res. Commun. 374 (2). United States: 294–8. doi:10.1016/j.bbrc.2008.07.019. PMID 18627766.

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TRIP12

Interactions

References

Further reading