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Uncoupling (neuropsychopharmacology)

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In neuropsychopharmacology, uncoupling, also known as decoupling, is the process of receptor- or ligand-binding sites or domains becoming separated, moving alignments and/or becoming internalised as a result of drug tolerance resulting from prolonged exposure to bioavailable psychoactive substances or toxins.^[1]^[2]

References

^ Mize, Amy L; Alpher, Richard H. "Rapid uncoupling of serotonin-1A receptors in rat hippocampus by 17(beta)-estradiol in vitro requires protein kinases A and C". Neuroendocrinology. ProQuest 220112648 – via ProQuest.
^ Ganguly, Prabarna; Holland, Freedom H; Brenhouse, Heather C. "Functional Uncoupling NMDAR NR2A Subunit from PSD-95 in the Prefrontal Cortex: Effects on Behavioral Dysfunction and Parvalbumin Loss after Early-Life Stress". Neuropsychopharmacology. ProQuest 1721699997.

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