GPR37 has been shown to interact with HSPA1A[9] and Parkin (ligase).[9][10] GPR37 is a receptor for prosaposin. It was previously thought to be a receptor for head activator, a neuropeptide found in the hydra, but early reports of head activator in mammals were never confirmed.[11] To address challenges in confirming ligand-GPR37 interactions using recombinant GPR37 expressed in HEK293 cells, recent research has turned to primary cell cultures, leading to successful ligand identification.[12] These investigations have unveiled the involvement of osteocalcin with GPR37 to regulate processes such as oligodendrocyte differentiation, myelination, myelin production, and remyelination following demyelinating injuries.[13] Furthermore, osteocalcin treatment has demonstrated protective effects against Lipopolysaccharide-induced inflammation, which are absent in GPR37-deficient mice.[14]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (October 1997). "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library". Genomics. 45 (1): 68–77. doi:10.1006/geno.1997.4900. PMID9339362.
Zeng Z, Su K, Kyaw H, Li Y (April 1997). "A novel endothelin receptor type-B-like gene enriched in the brain". Biochemical and Biophysical Research Communications. 233 (2): 559–567. doi:10.1006/bbrc.1997.6408. PMID9144577.
Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, et al. (December 2006). "A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin". Journal of Neurochemistry. 99 (6): 1456–1469. doi:10.1111/j.1471-4159.2006.04155.x. hdl:2115/17141. PMID17059562. S2CID6256027.
