TAS2R3

TAS2R3
Identifiers
Aliases	TAS2R3, T2R3, taste 2 receptor member 3
External IDs	OMIM: 604868; MGI: 3606604; HomoloGene: 23231; GeneCards: TAS2R3; OMA:TAS2R3 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	141,765,197 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	40,469,239 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; epithelium of colon; ; Achilles tendon; ; tonsil; ; right hemisphere of cerebellum; ; right uterine tube; ; urinary bladder; ; ovary; ; body of uterus; ; muscle of thigh;
	Top expressed in
	embryo; ; primary oocyte; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; taste receptor activity; bitter taste receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	detection of chemical stimulus involved in sensory perception of bitter taste; sensory perception of taste; signal transduction; response to stimulus; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	50831
	574417
	ENSG00000127362
	ENSMUSG00000052850
	Q9NYW6
	Q7TQA7
	NM_016943
	NM_001025385
	NP_058639
	NP_001020556
	Wikidata
View/Edit Human	View/Edit Mouse

Taste receptor type 2 member 3 is a protein that in humans is encoded by the TAS2R3 gene.^[5]

Function

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.^[5]

Ligands

The only known ligand for TAS2R3 in BitterDB is chloroquine.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127362 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052850 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: TAS2R3 taste receptor, type 2, member 3".
^ "hTAS2R3". BitterDB. The Hebrew University of Jerusalem.

Kinnamon SC (2000). "A plethora of taste receptors". Neuron. 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719.
Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982. S2CID 37807140.
Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934. S2CID 14604586.
Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell. 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935. S2CID 7293493.
Firestein S (2000). "The good taste of genomics". Nature. 404 (6778): 552–3. doi:10.1038/35007167. PMID 10766221. S2CID 35741332.
Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. Bibcode:2000Natur.404..601M. doi:10.1038/35007072. PMID 10766242. S2CID 4336913.
Ueda T, Ugawa S, Ishida Y, Shibata Y, Murakami S, Shimada S (2001). "Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting". Biochem. Biophys. Res. Commun. 285 (1): 147–51. doi:10.1006/bbrc.2001.5136. PMID 11437385.
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520. S2CID 718601.
Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.
Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127362 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052850 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TAS2R3 taste receptor, type 2, member 3".

[bitterdb-6] "hTAS2R3". BitterDB. The Hebrew University of Jerusalem.

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TAS2R3

Function

Ligands

See also

References

Further reading