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Tipindole

Not to be confused with Tepirindole.
Tipindole
Clinical data
Other namesTipindol; Typindol; Typindole
Identifiers
  • 2-(dimethylamino)ethyl 1,3,4,5-tetrahydrothiopyrano[4,3-b]indole-8-carboxylate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H20N2O2S
Molar mass304.41 g·mol−1
3D model (JSmol)
  • CN(C)CCOC(=O)C1=CC2=C(C=C1)NC3=C2CSCC3
  • InChI=1S/C16H20N2O2S/c1-18(2)6-7-20-16(19)11-3-4-14-12(9-11)13-10-21-8-5-15(13)17-14/h3-4,9,17H,5-8,10H2,1-2H3
  • Key:WNDHLINIYZAWCR-UHFFFAOYSA-N

Tipindole (INNTooltip International Nonproprietary Name), also known as typindole, is a drug of the tricyclic family described as a serotonin antagonist and monoamine oxidase inhibitor (MAOI) which was never marketed.[1][2][3][4] The drug was developed by Soviet researchers and was first described by 1962.[3]

See also

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References

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  1. ^ Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 1-PA287. ISBN 978-1-4757-2085-3. Retrieved 20 October 2024.
  2. ^ "Tipindole". Inxight Drugs. National Center for Advancing Translational Sciences. Retrieved 20 October 2024.
  3. ^ a b Aksanova LA, Pidevich IN, Sharkova LM, Kucherova NF (1968). "Indole derivatives". Pharmaceutical Chemistry Journal. 2 (7). Springer Science and Business Media LLC: 353–359. doi:10.1007/bf00759600. ISSN 0091-150X.
  4. ^ Ramsay RR, Gravestock MB (March 2003). "Monoamine oxidases: to inhibit or not to inhibit". Mini Reviews in Medicinal Chemistry. 3 (2): 129–136. doi:10.2174/1389557033405287. PMID 12570845. A screen using this model identified not only known MAO inhibitors (MAOI) but also similar rigid cyclic compounds such as tipindole, a 5HT receptor agonist, [...]
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