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Lead(II) acetate

Lead(II) acetate
Skeletal formula of lead(II) acetate
Toxic lead sugar or lead(II) acetate
Names
IUPAC name
Lead(II) acetate
Systematic IUPAC name
Lead(II) ethanoate
Other names
Plumbous acetate, Sugar of Lead, lead diacetate, lead sugar, Salt of Saturn, Goulard's powder
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.005.551 Edit this at Wikidata
EC Number
  • 206-104-4
MeSH lead+acetate
RTECS number
  • OF8050000
UNII
  • InChI=1S/2C2H4O2.Pb/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2 ☒N
    Key: GUWSLQUAAYEZAF-UHFFFAOYSA-L ☒N
  • CC(=O)[O-].CC(=O)[O-].[Pb+2]
Properties
Pb(C2H3O2)2
Molar mass 325.29 g/mol (anhydrous)
379.33g/mol (trihydrate)
Appearance White powder or colourless, efflorescent crystals
Odor Slightly acetic
Density 3.25 g/cm3 (20 °C, anhydrous)
2.55 g/cm3 (trihydrate)
1.69 g/cm3 (decahydrate)[1]
Melting point 280 °C (536 °F; 553 K) (anhydrous)
75 °C (167 °F; 348 K)
(trihydrate) decomposes[4] at ≥ 200 °C
22 °C (72 °F; 295 K)
(decahydrate)[1]
Boiling point Decomposes
Anhydrous:
19.8 g/100 mL (0 °C)
44.31 g/100 mL (20 °C)
69.5 g/100 mL (30 °C)[2]
218.3 g/100 mL (50 °C)[1]
Solubility Anhydrous and trihydrate are soluble in alcohol, glycerol[2]
Solubility in methanol Anhydrous:[2]
102.75 g/100 g (66.1 °C)
Trihydrate:[3]
74.75 g/100 g (15 °C)
214.95 g/100 g (66.1 °C)
Solubility in glycerol Anhydrous:[2]
20 g/100 g (15 °C)
Trihydrate:[3]
143 g/100 g (20 °C)
−89.1·10−6 cm3/mol
1.567 (trihydrate)[1]
Structure
Monoclinic (anhydrous, trihydrate)
Rhombic (decahydrate)
Thermochemistry
−960.9 kJ/mol (anhydrous)[2]
−1848.6 kJ/mol (trihydrate)[3]
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Neurotoxic, probable human carcinogen
GHS labelling:
GHS08: Health hazard GHS09: Environmental hazard[4]
Danger
H360, H373, H410[4]
P201, P273, P308+P313, P501[4]
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g. chloroformFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 1: Normally stable, but can become unstable at elevated temperatures and pressures. E.g. calciumSpecial hazards (white): no code
2
1
1
Flash point Non-flammable
Lethal dose or concentration (LD, LC):
400 mg/kg (mice, oral)[1]
300 mg/kg (dog, oral)[5]
Related compounds
Other cations
 Lead(IV) acetate
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Lead(II) acetate is a white crystalline chemical compound with a slightly sweet taste. Its chemical formula is usually expressed as Pb(CH3COO)2 or Pb(OAc)2, where Ac represents the acetyl group. Like many other lead compounds, it causes lead poisoning. Lead acetate is soluble in water and glycerin. With water it forms the trihydrate, Pb(OAc)2·3H2O, a colourless or white efflorescent monoclinic crystalline substance.

The substance is used as a reagent to make other lead compounds and as a fixative for some dyes. In low concentrations, it formerly served as the principal active ingredient in progressive types of hair colouring dyes.[6] Lead(II) acetate is also used as a mordant in textile printing and dyeing, and as a drier in paints and varnishes. It was historically used as a sweetener and preservative in wines and in other foods and for cosmetics.

Production

[edit]

Lead(II) acetate can be made by boiling elemental lead in acetic acid and hydrogen peroxide. This method will also work with lead(II) carbonate or lead(II) oxide.

Pb + H2O2 + 2 H+ → Pb2+ + 2 H2O
Pb2+ + 2 AcO− → Pb(OAc)2

Lead(II) acetate can also be made by dissolving lead(II) oxide in acetic acid:[7]

PbO + 2 AcOH → Pb(OAc)2 + H2O

Lead(II) acetate can also be made via a single-displacement reaction between copper acetate and lead metal:

Cu(OAc)2 + Pb → Cu + Pb(OAc)2

Structure

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The crystal structure of anhydrous lead(II) acetate has been described as a 2D coordination polymer. In comparison, lead(II) acetate trihydrate's structure is a 1D coordination polymer.[8] In the trihydrate, the Pb2+ ion's coordination sphere consists of nine oxygen atoms belonging to three water molecules, two bidentate acetate groups and two bridging acetate groups. The coordination geometry at Pb is a monocapped square antiprism.[9][10] The trihydrate thermally decomposes to a hemihydrate, Pb(OAc)2·1⁄2H2O, and to basic acetates such as Pb4O(OAc)6 and Pb2O(OAc)2.[8]

Comparison of anhydrous and trihydrate crystal structures
Anhydrous[8]
Pb(OAc)2 		Trihydrate[9][10]
Pb(OAc)2·3H2O
Lead
coordination
sphere
Strongly bonded
aggregation
2D sheet
1D chain
Weakly bonded
aggregation
sheets stacked with
hydrophobic surfaces in contact
chains linked by hydrogen bonds

Uses

[edit]

Lead acetate is used as a precursor to other lead compounds such as the various carbonate.

Niche and laboratory uses

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Lead(II) acetate paper is used to detect the poisonous gas hydrogen sulfide. The gas reacts with lead(II) acetate on the moistened test paper to form a grey precipitate of lead(II) sulfide.

An aqueous solution of lead(II) acetate is a byproduct of the process used in the cleaning and maintenance of stainless steel firearm suppressors (silencers) and compensators when using a 1:1 ratio of hydrogen peroxide and white vinegar (acetic acid). The solution is agitated by the bubbling action of the hydrogen peroxide, with the main reaction being the oxidation of lead by hydrogen peroxide and subsequent dissolution of lead oxide by the acetic acid, which forms lead acetate. Because of its high toxicity, this chemical solution must be appropriately disposed by a chemical processing facility or hazardous materials centre. Alternatively, the solution may be reacted with sulfuric acid to precipitate nearly insoluble lead(II) sulfate. The solid may then be removed by mechanical filtration and is safer to dispose of than aqueous lead acetate.

Historical uses

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Sweetener

[edit]

Like other lead(II) salts, lead(II) acetate has a sweet taste, which led to its historical use as a sugar substitute in both wines and foods.[11] The ancient Romans, who had few sweeteners besides honey, would boil must (unfiltered grape juice) in lead pots to produce a reduced sugar syrup called defrutum, concentrated again into sapa. This syrup was used to sweeten wine and to sweeten and preserve fruit. It is possible that lead(II) acetate or other lead compounds leaching into the syrup might have caused lead poisoning in those who consumed it.[12] Lead acetate is no longer used in the production of sweeteners because of its recognized toxicity. Legislation prohibiting its use as a wine sweetener was ineffective until decades later, when chemical methods of detecting its presence had been developed.[13]

The earliest confirmed poisoning by lead acetate was that of Pope Clement II, who died in October 1047. A toxicological examination of his remains conducted in the mid-20th century confirmed centuries-old rumors that he had been poisoned with lead sugar.[14] It is not clear whether he was assassinated.

In 1787 painter and biographer Albert Christoph Dies swallowed, by accident, approximately 3/4 ounce (20 g) of lead acetate. His recovery from this poison was slow and incomplete. He lived with illnesses until his death in 1822.[15][16]

Although the use of lead(II) acetate as a sweetener was already illegal at that time, composer Ludwig van Beethoven may have died of lead poisoning caused by wines adulterated with lead acetate (see also Beethoven's liver).[17][18]

In 1887, 38 hunting horses belonging to Captain William Hollwey Steeds were poisoned in their stables at Clonsilla House, Dublin, Ireland. At least ten of the hunters died. Captain Steeds, an "extensive commission agent", had previously supplied the horses for the Bray and Greystones Coach. It transpired that they had been fed a bran mash that had been sweetened with a toxic lead acetate.[19]

Cosmetics

[edit]

Lead(II) acetate and white lead have been used in cosmetics throughout history.[20]

It was once used for men's hair colouring products[21] like Grecian Formula. The manufacturer did not remove lead acetate from its product until 2018. Lead acetate has been replaced by bismuth citrate as the progressive colorant. Its use in cosmetics has been banned in Canada by Health Canada since 2005 (effective at the end of 2006) based on tests showing possible carcinogenicity and reproductive toxicity,[22] and it is also banned in the European Union.[22]

Medical uses

[edit]

Lead(II) acetate solution was a commonly used folk remedy for sore nipples.[23] In modern medicine, for a time, it was used as an astringent, in the form of Goulard's extract, and it has also been used to treat poison ivy.[24]

In the 1850s, Mary Seacole applied lead(II) acetate, among other remedies, against an epidemic of cholera in Panama.[25][26]

Other historic uses

[edit]

It was also used in making of slow matches during the Middle Ages. It was made by mixing a natural form of lead(II) oxide called litharge and vinegar.

Sugar of lead was a recommended agent added to linseed oil during heating to produce "boiled" linseed oil, the lead and heat acting to cause the oil to cure faster than raw linseed oil.[27]

Lead(II) acetate ("salt of Saturn") was used to synthesise acetone which was then known as "spirit of Saturn" for being made with the salt of Saturn and thought to be a lead compound in the 17th century.[28]

See also

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References

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  1. ^ a b c d e Pradyot, Patnaik (2003). Handbook of Inorganic Chemicals. The McGraw-Hill Companies, Inc. ISBN 0-07-049439-8.
  2. ^ a b c d e "Lead(II) acetate". chemister.ru.
  3. ^ a b c "Lead(II) acetate trihydrate". chemister.ru.
  4. ^ a b c d Sigma-Aldrich Co., Lead(II) acetate trihydrate.
  5. ^ "Lead compounds (as Pb)". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
  6. ^ "Lead Acetate in 'Progressive' Hair Dye Products". fda.gov. 7 October 2021.
  7. ^ Greenwood, Norman N.; Earnshaw, Alan (1997). Chemistry of the Elements (2nd ed.). Butterworth-Heinemann. pp. 373, 388. ISBN 978-0-08-037941-8.
  8. ^ a b c Martínez-Casado, Francisco J.; Ramos-Riesco, Miguel; Rodríguez-Cheda, José A.; Cucinotta, Fabio; Matesanz, Emilio; Miletto, Ivana; Gianotti, Enrica; Marchese, Leonardo; Matěj, Zdeněk (2016). "Unraveling the Decomposition Process of Lead(II) Acetate: Anhydrous Polymorphs, Hydrates, and Byproducts and Room Temperature Phosphorescence". Inorg. Chem. 55 (17): 8576–8585. doi:10.1021/acs.inorgchem.6b01116. PMID 27548299.
  9. ^ a b Rajaram, R. K.; Mohana Rao, J. K. (1982). "Crystal structure of lead acetate trihydrate". Z. Kristallogr. 160 (1–4): 225–233. doi:10.1524/zkri.1982.160.14.225. S2CID 201671682.
  10. ^ a b Bryant, Robert G.; Chacko, V. P.; Etter, Margaret C. (1984). "Carbon-13 CP/MAS NMR and crystallographic investigations of the structure and solid-state transformations of lead(II) acetate trihydrate". Inorg. Chem. 23 (22): 3580–3584. doi:10.1021/ic00190a029.
  11. ^ "The Disturbingly Long History of Lead Toxicity in Winemaking." Anna Archibald, 30 July 2020. Retrieved: 22 December, 2020.
  12. ^ "Lead Poisoning and Rome". penelope.uchicago.edu. Retrieved 5 May 2024.
  13. ^ Stoeppler, M. (1992), Hazardous Metals in the Environment, Techniques and Instrumentation in Analytical Chemistry, vol. 12, Elsevier, p. 60, ISBN 9780080875606, From the results achieved so far it is obvious that the purity law for lead in wines in the last two centuries was frequently ignored.
  14. ^ Specht, W. and Fischer, K. (1959). "Vergiftungsnachweis an den Resten einer 900 Jahre alten Leiche" [Evidence of poisoning in the remains of a 900-year-old corpse] (in German). Archiv für Kriminologie 124: 61–84.
  15. ^  One or more of the preceding sentences incorporates text from a publication now in the public domain: Chisholm, Hugh, ed. (1911). "Dies, Christoph Albert". Encyclopædia Britannica. Vol. 8 (11th ed.). Cambridge University Press. p. 211.
  16. ^ Dies, Albert Christoph (1810). Biographische Nachrichten von Joseph Haydn nach mündlichen Erzählungen desselben entworfen und herausgegeben [Biographical Accounts of Joseph Haydn, written and edited from his own spoken narratives]. Vienna: Camesinaische Buchhandlung. English translation in: Dies, Albert Christoph (1963). "Biographical Accounts of Joseph Haydn". In Gotwals, Vernon (ed.). Haydn: Two Contemporary Portraits. Translated by Gotwals, Vernon. Milwaukee: University of Wisconsin Press. ISBN 0-299-02791-0.
  17. ^ "Beethoven und Blei: Tödliches Zusammenspiel" [Beethoven and lead: deadly interaction]. pharmazeutische-zeitung.de. Archived from the original on 2009-02-21. Retrieved 2024-12-17.
  18. ^ "Beethoven litt unter Bleivergiftung" [Beethoven suffered from lead poisoning]. 3sat.de. Archived from the original on 2009-02-21. Retrieved 2020-02-24.
  19. ^ Weekly Irish Times, Saturday 15 October 1887; Enniskillen Chronicle and Erne Packet, 24 October 1887, p. 3
  20. ^ Gunn, Fenja. (1973) The Artificial Face: A History of Cosmetics. — as cited in Leisure Activities of an 18th Century Lady websites.umich.edu
  21. ^ Lead Based Hair Products: Too Hazardous for Household Use - Results, Howard W. Mielke, PhD, Myiesha D. Taylor, Chris R. Gonzales, M. Kelley Smith, Pamela V. Daniels, and Ayanna V.Buckner. Journal of American Pharmaceutical Association (NS37, Jan/Feb 1997:85-89).
  22. ^ a b "Can West News Service: Grecian Formula in a grey zone after ban". canada.com. Archived from the original on 2007-08-08.
  23. ^ The American Frugal Housewife, by Lydia M. Child gutenberg.org
  24. ^ Laboratory manual in biology. Sharpe. 1911, American Book Company. p. 351
  25. ^ Mary Seacole (1990), Wonderful Adventures of Mrs. Seacole in Many Lands, Chapter IV, Oxford University Press reprint, ISBN 0-19-506672-3; (2005 Penguin 20th Century Classics reprint, ed. Sarah Salih) ISBN 0-14-043902-1
  26. ^ Jane Robinson (2004), Mary Seacole: The Charismatic Black Nurse who became a heroine of the Crimea, p.53. Constable ISBN 1-84119-677-0
  27. ^ Andés, Louis Edgar, and Arthur Morris. Oil colours and printers' inks a practical handbook treating of linseed oil, boiled oil, paints, artists' colours, lampblack, and printers' inks, black and coloured. London: Scott, Greenwood. 1903. 41. Print.
  28. ^ Mel Gorman, History of acetone (1600–1850), 1962
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